It works by automatically tweaking the driver's ist, but a reboot will be required after any changes. I have added a version of the driver without support for the Guitar Hero controller, to allow the Guitar Hero for Mac game to work (it attempts to access hardware directly, which doesn't work if a real driver has claimed the device). Sadly, my PowerMac has died, which as my primary development machine has slowed progress. I've not yet checked the wireless receiver for compatibility. The latest release of the driver includes support, and I'll be updating the USB information section of this website shortly. I have got the Microsoft ChatPad working with my wired controller.
I have created a USB driver which allows you to use wired XBox 360 Controllers via USB, and wireless XBox 360 Controllers via the Microsoft Wireless Gaming Receiver for Windows, on your OSX machine, including support for the Apple Force Feedback library.